The Big Bang Theory is centered on five characters living in Pasadena, California: roommates Leonard Hofstadter and Sheldon Cooper; Penny, a waitress and aspiring actress who lives across the hall; and Leonard and Sheldon's equally geeky and socially awkward friends and co-workers, mechanical engineer Howard Wolowitz and astrophysicist Raj Koothrappali. The geekiness and intellect of the four guys is contrasted for comic effect with Penny's social skills and common sense.
University physicists Leonard and Sheldon know whether to use an integral or a differential to solve the area under a curve. But they don't have a clue about girls. Or dating. Or clothes. Or parties. Or having fun. Or, basically, life. So when a pretty blonde named Penny moves in the apartment across the hall, the guys decide to get an education outside of the classroom. Boys, you have a lot to learn.